Affiliation:
1. Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada
2. Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA
Abstract
ABSTRACT
The genus
Acinetobacter
encompasses multiple nosocomial opportunistic pathogens that are of increasing worldwide relevance because of their ability to survive exposure to various antimicrobial and sterilization agents. Among these,
Acinetobacter baumannii
,
Acinetobacter nosocomialis
, and
Acinetobacter pittii
are the most frequently isolated in hospitals around the world. Despite the growing incidence of multidrug-resistant
Acinetobacter
spp., little is known about the factors that contribute to pathogenesis. New strategies for treating and managing infections caused by multidrug-resistant
Acinetobacter
strains are urgently needed, and this requires a detailed understanding of the pathobiology of these organisms. In recent years, some virulence factors important for
Acinetobacter
colonization have started to emerge. In this review, we focus on several recently described virulence factors that act at the bacterial surface level, such as the capsule,
O
-linked protein glycosylation, and adhesins. Furthermore, we describe the current knowledge regarding the type II and type VI secretion systems present in these strains.
Funder
Washington University School of Medicine
Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
104 articles.
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