First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Single Doses of NTM-1633, a Novel Mixture of Monoclonal Antibodies against Botulinum Toxin E-Reference-Cited by-同舟云学术

First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Single Doses of NTM-1633, a Novel Mixture of Monoclonal Antibodies against Botulinum Toxin E

Published:2022-04-19 Issue:4 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Raja S. M.¹²^ORCID,Guptill J. T.¹²³,Juel V. C.¹,Walter E. B.⁴⁵,Cohen-Wolkowiez M.²³⁴,Hill H.⁶,Sendra E.⁶,Hauser B.²,Jackson P.⁵,Tomic M.⁷,Espinoza Y.⁷,Swamy G. K.⁵⁸^ORCID

Affiliation:

1. Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA

2. Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA

3. Duke Clinical Research Institute, Durham, North Carolina, USA

4. Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA

5. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA

6. The EMMES Corporation, Rockville, Maryland, USA

7. Ology Bioservices Incorporated, Alameda, California, USA

8. Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

Botulism is a rare, life-threatening paralytic disease caused by botulinum neurotoxin (BoNT). Available treatments including an equine antitoxin and human immune globulin are given postexposure and challenging to produce and administer.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01732-21

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1. The Most Poisonous Poison