Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid

Published:2016-04 Issue:4 Volume:60 Page:2542-2544
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhang Shuo¹,Chen Jiazhen²,Cui Peng²,Shi Wanliang¹,Shi Xiaohong³,Niu Hongxia⁴,Chan Denise⁵,Yew Wing Wai⁵,Zhang Wenhong²,Zhang Ying¹²

Affiliation:

1. Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

2. Key Lab of Molecular Virology, Institute of Medical Microbiology, Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

3. Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China

4. Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China

5. Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China

Abstract

ABSTRACT Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02941-15

Reference14 articles.

1. The emerging problem of linezolid-resistant Staphylococcus

2. Linezolid for the Treatment of Multidrug‐Resistant, Gram‐Positive Infections: Experience from a Compassionate‐Use Program

3. The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria

4. Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

5. Linezolid in the Treatment of Multidrug‐Resistant Tuberculosis

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