ENZYMATIC DETOXIFICATION OF WOUNDS: THREE GENERATIONS OF DRUGS

Abstract

The formation of significant amounts of tissue decay products is an integral part of the pathogenesis of chronic superficial lesions of various etiologies. This significantly complicates the healing process and contributes to the chronicity and deepening of the pathological process. For detoxification ofsuch wounds, proteolytic enzymes are used widely, whose hydrolytic action helps to break down the protein components of endogenous intoxication and clean the wound. Three generations of enzymatic preparations for this purpose can be distinguished. The first one includes soluble forms of enzymes that are still quite successfully used in clinical practice. The second generation contains preparations of enzymes immobilized on insoluble fiber carriers. Immobilization allows you to bypass a number of disadvantages inherent in the first generation drugs. The development of this direction was the creation of heterophasic enzyme-containing macroporous granules embedded in a hydrophilic bactericidal gel. The significant advantages of this kind of composition allows us to talk about them as the third generation of drugs for enzymatic detoxification. This work examines the genesis of the creation of drugs of all three generations, examples of their use, characteristic advantages and disadvantages.