FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET OF PARACETAMOL AND ORPHENADRINE CITRATE BY DIRECT COMPRESSION METHOD

Abstract

The objective of this research work was to formulate, develop and evaluate immediate release tablet of paracetamol and orphenadrine citrate by direct compression method. Paracetamol which is antipyretic and orphenadrine citrate is skeletal muscle relaxant. The drug paracetamol and orphenadrine citrate was taken and formulated with different concentration of cross-povidone, mannitol, micro-crystalline cellulose, magnesium stearate and talc. Where cross-povidone as a superdisintegrant, mannitol as diluent, micro-crystalline cellulose as binder, magnesium stearate as lubricant and talc as a glidant used. the preformulation parameters such as bulk density, tapped density, compressibility index and hausner’s ratio were analysed. The thickness, hardness, friability, weight variation, disintegration time & drug content uniformity was evaluated. the in-vitro drug release studied were performed in the usp type (ii) paddle using 0.1N HCl as a dissolution media at 75 rpm speed and temperature of 37±0.5ºC. The % drug release at different time interval was estimated using UV method. Based on the evaluation result f9 trial was selected as the best formulation. The in-vitro drug release profile of the drugs was compared with marketed reference product. All the evaluated result was found to be satisfied with the reference products.