Mouse models of endocrine tumors

Author:

Gahete Manuel D12345,Jiménez-Vacas Juan M12345,Alors-Pérez Emilia12345,Herrero-Aguayo Vicente12345,Fuentes-Fayos Antonio C12345,Pedraza-Arévalo Sergio12345,Castaño Justo P12345,Luque Raúl M12345

Affiliation:

1. 1Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain

2. 2Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain

3. 3Reina Sofia University Hospital, Córdoba, Spain

4. 4CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

5. 5Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

Abstract

Endocrine and neuroendocrine tumors comprise a highly heterogeneous group of neoplasms that can arise from (neuro)endocrine cells, either from endocrine glands or from the widespread diffuse neuroendocrine system, and, consequently, are widely distributed throughout the body. Due to their diversity, heterogeneity and limited incidence, studying in detail the molecular and genetic alterations that underlie their development and progression is still a highly elusive task. This, in turn, hinders the discovery of novel therapeutic options for these tumors. To circumvent these limitations, numerous mouse models of endocrine and neuroendocrine tumors have been developed, characterized and used in preclinical, co-clinical (implemented in mouse models and patients simultaneously) and post-clinical studies, for they represent powerful and necessary tools in basic and translational tumor biology research. Indeed, different in vivo mouse models, including cell line-based xenografts (CDXs), patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMs), have been used to delineate the development, progression and behavior of human tumors. Results gained with these in vivo models have facilitated the clinical application in patients of diverse breakthrough discoveries made in this field. Herein, we review the generation, characterization and translatability of the most prominent mouse models of endocrine and neuroendocrine tumors reported to date, as well as the most relevant clinical implications obtained for each endocrine and neuroendocrine tumor type.

Publisher

Bioscientifica

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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