EFFECT OF ANTIGAMMAGLOBULIN-THYROXINE COMPLEX ON THE UREA EXCRETION OF TADPOLES

Abstract

ABSTRACT Antithyroglobulin (antigammaglobulin) isolated from thyroglobulin immunized rabbit sera inhibited the thyroxine-induced urea excretion and tail resorption in tadpoles. Albumin produced similar effects. Normal gammaglobulin fraction from rabbit sera or gammaglobulin, Fr. II, did not inhibit the action of T4 in tadpoles. The physiological consequence of thyroxine-protein binding is discussed.