EFFECTS OF NEONATALLY INJECTED NON-ESTERIFIED TESTOSTERONE ON REPRODUCTIVE FUNCTIONS IN FEMALE RATS

Abstract

ABSTRACT The effect of 1.5 mg testosterone (T) given to neonatal rats of various ages was compared with that of 1.5 mg testosterone propionate (Tp) injected into 5 day old rats. Androgenization of the rats was obtained: with Tp in 100 per cent, with T on day 2 in 79 per cent, with T on day 5 in 50 per cent, with T on day 10 in 18 per cent, with a double dose of T on day 5 in 61 per cent, with T on day 5 and 10 in 100 per cent. The results emphasize the importance of the duration of action of the preparation given. The possibility is considered that a minimal exposure time of more than a few hours is required to produce androgenization of 5 day old female rats.