Author:
Lerner U.,Gustafson G. T.
Abstract
ABSTRACT
The effect of N6,O2′-dibutyryl adenosine 3′,5′-cyclic-monophosphate (dbcAMP) on the mobilization of calcium (Ca2 +), inorganic phosphate (Pi) and lysosomal enzymes was studied in a bone culture system for 24 h using half calvaria from 6–7 day-old mice. DbcAMP inhibited spontaneous as well as parathyroid hormone-stimulated mineral mobilization. DbcAMP in a concentration of 5 × 10−4m also reduced the activities of β-glucuronidase, β-galactosidase and acid phosphatase found in the media while the activities of lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase were not affected. It is concluded that cAMP is not a stimulator but an inhibitor of bone resorption within the culture period studied (24 h) and that the cyclic nucleotide might interfere with release processes involved in bone resorption.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
31 articles.
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