AN EXPERIMENTAL STUDY TO COMPARE OUTCOMES BETWEEN ANIMALS & HUMAN AFTER SINGLE ISONIAZID (INH) ORAL DOSE TO TREAT VARIOUS INFECTIONS

Objective: Research objective was the investigation of isoniazid bio-disposition in the “Teddy Goats”.

Material and Methods: Our experimental research was carried out at Sir Ganga Ram Hospital, Lahore in coordination with agriculture university from March, 2016 to January, 2017 in order to investigate the isoniazid (INH) Bio-disposition after the administering of single oral dose at (10 mg / Kg) according to the body weight of the Teddy goats. Each animal was drained for blood sample at pre-determined interval form the time of oral dose administration. Isolation of plasma was made through centrifuge process and it was analyzed through spectrophotometer for INH.

Results: Concentration Vs profile of time of every goat was used for the INH bio-disposition determination. Two compartments were used for the description of the data; open pharmacokinetic (PK) model and numerous parameters of the PK were measured and those were observed non-comparable with the available literature.

Conclusions: On the basis of the research outcomes we can conclude that imported antimicrobial drugs disposition studies are to be conducted in the presence of native conditions in order to make them rational with the regimen of dose in the local species of the animals.

Keywords: Isoniazid, Bio-disposition, Teddy goats and Spectrophotometer.