Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery

Author:

Farnoud Ali12ORCID,Tofighian Hesam3,Baumann Ingo4,Garcia Guilherme J. M.5ORCID,Schmid Otmar12ORCID,Gutheil Eva6,Rashidi Mohammad Mehdi789ORCID

Affiliation:

1. Comprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany

2. Institute of Lung Biology and Disease, Helmholtz Zentrum München, 85764 Neuherberg, Germany

3. Mechanical Engineering Department, Amirkabir University of Technology, Tehran, Iran

4. Department of Otorhinolaryngology, Head and Neck Surgery, Medical Center of Heidelberg University, Heidelberg, Germany

5. Department of Biomedical Engineering, Marquette University & The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA

6. Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany

7. Shanghai Automotive Wind Tunnel Center, Tongji University, Shanghai 201804, China

8. Institute of Fundamental and Frontier Sciences, University of Electronic and Technology of China, Chengdu 610054, Sichuan, People’s Republic of China

9. Faculty of Mechanical and Industrial Engineering, Quchan University of Technology, Quchan, Iran

Publisher

AIP Publishing

Subject

Condensed Matter Physics,Fluid Flow and Transfer Processes,Mechanics of Materials,Computational Mechanics,Mechanical Engineering

Reference70 articles.

1. Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study

2. D. L. Blackwell, J. W. Lucas, and T. C. Clarke, Summary Health Statistics for U.S. Adults: National Health Interview Survey, 2012, Vital and Health Statistics, Series 10 (U.S. Department of Health and Human Services, 2014), pp. 1–161, Data from the National Health Survey.

3. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists

4. Current understanding of nasal morphology and physiology as a drug delivery target

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