Enzyme localization, crowding, and buffers collectively modulate diffusion-influenced signal transduction: Insights from continuum diffusion modeling
Author:
Affiliation:
1. Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA
2. Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093-0365, USA
Funder
National Science Foundation (NSF)
National Institutes of Health (NIH)
American Heart Association (AHA)
Publisher
AIP Publishing
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://aip.scitation.org/doi/pdf/10.1063/1.4929528
Reference67 articles.
1. Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences
2. Models of macromolecular crowding effects and the need for quantitative comparisons with experiment
3. Crowding Effects on Diffusion in Solutions and Cells
4. Influence of neighboring reactive particles on diffusion-limited reactions
5. A model study of sequential enzyme reactions and electrostatic channeling
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