Affiliation:
1. Department of Biomedical Engineering, The Hong Kong Polytechnic University 1 , Kowloon 999077, Hong Kong SAR, People's Republic of China
2. Department of Mechanical and Automotive Engineering, Royal Melbourne Institute of Technology 2 , Melbourne, VIC 3000, Australia
Abstract
With the global outbreak of SARS-CoV-2, the inadequacies of current detection technology for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive assays are needed to expedite diagnosis and early intervention. Conventional methods for detection of respiratory viruses include cell culture-based assays, serological tests, nucleic acid detection (e.g., RT-PCR), and direct immunoassays. However, these traditional methods are often time-consuming, labor-intensive, and require laboratory facilities, which cannot meet the testing needs, especially during pandemics of respiratory diseases, such as COVID-19. Microfluidics-based techniques can overcome these demerits and provide simple, rapid, accurate, and cost-effective analysis of intact virus, viral antigen/antibody, and viral nucleic acids. This review aims to summarize the recent development of microfluidics-based techniques for detection of respiratory viruses. Recent advances in different types of microfluidic devices for respiratory virus diagnostics are highlighted, including paper-based microfluidics, continuous-flow microfluidics, and droplet-based microfluidics. Finally, the future development of microfluidic technologies for respiratory virus diagnostics is discussed.
Funder
Shenzhen-HongKong-Macao Science and Technology Plan Scheme
Research Grants Council, University Grants Committee
The Innovation Technology Fund Guangdong-Hongkong Cooperation Funding Scheme
The Hong Kong Polytechnic University Shenzhen Institute Bai Cheng Bai Yuan Fund
The Hong Kong Polytechnic University Internal Fund
Subject
Condensed Matter Physics,General Materials Science,Fluid Flow and Transfer Processes,Colloid and Surface Chemistry,Biomedical Engineering
Cited by
2 articles.
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