Rupture of membranous microbubbles induced by pulsed acoustic wave

Abstract

Encapsulated microbubbles serve as suitable drug carriers in medicine. This paper proposes corrections for the resonance frequency of lipid-coated bubbles under various acoustic pressure levels and the critical pressure for bubble rupture based on the Marmottant model. The suggestion to induce the rupture of lipid-coated bubbles using acoustic waves leans toward utilizing pulse waves rather than continuous waves. Corresponding experiments validate the accuracy of these corrections and the rationale behind the suggestion, aligning closely with theoretical predictions. This study offers a more precise predictive framework for the behavior of lipid-coated bubbles under acoustic waves.