Ultrasound-based surface sampling in immersion for mass spectrometry-Reference-Cited by-同舟云学术

Ultrasound-based surface sampling in immersion for mass spectrometry

Published:2023-09-08 Issue:10 Volume:134 Page:
ISSN:0021-8979
Container-title:Journal of Applied Physics
language:en
Short-container-title:

Author:

Sillanpää Tom¹^ORCID,Hyvönen Jere²^ORCID,Mäkinen Joni²^ORCID,Holmström Axi²^ORCID,Pudas Topi²^ORCID,Lassila Petri²^ORCID,Lepistö Riikka¹^ORCID,Kuronen Antti³^ORCID,Kotiaho Tapio¹⁴^ORCID,Hæggström Edward²,Salmi Ari²^ORCID

Affiliation:

1. 1 Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland

2. 2 Electronics Research Laboratory, Department of Physics, University of Helsinki, P.O. Box 64, FI-00014 Helsinki, Finland

3. 3 Department of Physics, University of Helsinki, P.O. Box 64, FI-00014 Helsinki, Finland

4. 4 Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland

Abstract

We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample distance was determined using the actuating ultrasound transducer prior to sampling, allowing sonication in focus despite surface height variation. We demonstrate the proposed surface sampling method on water-submerged glass cover slides painted with permanent markers, achieving sampling with tunable spot size down to 500 μm. The removed and collected material was transferred for chemical analysis by electrospray ionization mass spectrometry, which showed mass peaks characteristic to the permanent markers.

Funder

Academy of Finland

Publisher

AIP Publishing

Subject

General Physics and Astronomy

Link

https://pubs.aip.org/aip/jap/article-pdf/doi/10.1063/5.0157705/18117768/104901_1_5.0157705.pdf

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