REVERSIBLE INACTIVATION OF TYPHUS RICKETTSIAE

Author:

Bovarnick Marianna R.1,Allen Emma G.1

Affiliation:

1. From the Laboratory Service, Veterans Administration Hospital, Brooklyn, New York, and the Department of Medicine, State University of New York at New York City

Abstract

Rickettsiae that have been frozen and thawed in isotonic salt solutions show greatly decreased toxicity for mice, hemolytic activity, respiration, and infectivity for eggs. All these properties can be partially restored by incubation of the rickettsiae in the presence of DPN and coenzyme A for 2 hours at 34°C. The extent of both inactivation and of subsequent reactivation is markedly affected by the presence of low concentrations of sucrose during the process of freezing and thawing. It has been shown that DPN is present in rickettsial suspensions and that in preparations that have not been frozen, the DPN sediments with the rickettsiae. After freezing in isotonic salt solution the DPN becomes non-sedimentable.

Publisher

Rockefeller University Press

Subject

Physiology

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1. SOME ASPECTS OF VARIATION IN RICKETTSIAL VIRULENCE;Annals of the New York Academy of Sciences;2006-12-15

2. INVESTIGATION OF THE STABILITY OF THE TRACHOMA AGENT*;Annals of the New York Academy of Sciences;2006-12-15

3. Rickettsia prowazekii and Thymidylate Metabolism.;Annals of the New York Academy of Sciences;1990-06

4. Permeability of Rickettsia prowazekii to NAD;Journal of Bacteriology;1989-02

5. The effect of Anaplasma marginale on the glycolytic pathway in bovine erythrocytes;Comparative Biochemistry and Physiology Part B: Comparative Biochemistry;1984-01

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