Affiliation:
1. From the Department of Pharmacology, School of Medicine, San Juan, Puerto Rico, and the Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico
Abstract
The influence of several ions on the membrane potential of the somatic muscle of Ascaris has been investigated by changing their concentration in the surrounding solution. When [K]o is increased at the expense of [Na]oleaving [Cl]o constant, the membrane potential is first seen to increase. [K]o higher than 45 mM reduces the membrane potential with a slope of 23 mv for a tenfold change in [K]o. However, when [K]o is increased keeping [Na]o and [Cl]o low and constant, the line relating the membrane potential with log [K]o has a slope of almost 50 mv. If [Cl]o is reduced in the absence of external Na, after the [K]o is increased to 45 mM, the membrane potential decreases with a slope of 59 mv per tenfold change in [Cl]o in close agreement with the Nernst equation. If Cl- is replaced by SO42-, a depolarization is produced, while chloride replacement by NO3-, Br-, and I- results in a hyperpolarization of the membrane. Removal of the external Na+ ions increases the average membrane potential by 17 mv.
Publisher
Rockefeller University Press
Cited by
42 articles.
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