Influence of Some Ions on the Membrane Potential of Ascaris Muscle

Author:

Del Gastillo J.1,De Mello W. C.1,Morales T.1

Affiliation:

1. From the Department of Pharmacology, School of Medicine, San Juan, Puerto Rico, and the Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico

Abstract

The influence of several ions on the membrane potential of the somatic muscle of Ascaris has been investigated by changing their concentration in the surrounding solution. When [K]o is increased at the expense of [Na]oleaving [Cl]o constant, the membrane potential is first seen to increase. [K]o higher than 45 mM reduces the membrane potential with a slope of 23 mv for a tenfold change in [K]o. However, when [K]o is increased keeping [Na]o and [Cl]o low and constant, the line relating the membrane potential with log [K]o has a slope of almost 50 mv. If [Cl]o is reduced in the absence of external Na, after the [K]o is increased to 45 mM, the membrane potential decreases with a slope of 59 mv per tenfold change in [Cl]o in close agreement with the Nernst equation. If Cl- is replaced by SO42-, a depolarization is produced, while chloride replacement by NO3-, Br-, and I- results in a hyperpolarization of the membrane. Removal of the external Na+ ions increases the average membrane potential by 17 mv.

Publisher

Rockefeller University Press

Subject

Physiology

Cited by 42 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3