Analysis of antimicrobial protection factors of the pharyngeal tonsil surface in children with chronic adenoiditis

Abstract

The results of the clinical and immunological studies in 155 children aged 4–7 years with chronic adenoiditis, which have more than 6 ARI cases per year in their medical history with 3-6 relapses per year. The results showed that the children with chronic adenoiditis of bacterial etiology have 1.2 times higher number of viable neutrophilic granulocytes, the lysosomal activity thereof increased by 3.9 times, the activity decreased by 1.2 times and phagocytosis intensity – by 1.6 times, the inhibition of biocidal properties – by 2.3 times (according to the spontaneous NBT test), 2 times (according to the induced NBT test) in relative terms, accompanied by the decrease in secretory IgA – by 2.1 times, IL-1.beta – by 2.3 times IL-6 by 3.2 times, TNF-alpha by 3.1 times, the increase of IL-10 by 2.3 times, IL-8 – by 4.5 times, which contributes to the maintenance of chronic inflammation of the pharyngeal tonsil.