The correlation between clinical biochemical parameters and bone mineral density in postmenopausal women

Abstract

<b>Objective:</b> Menopause is characterized by the end of reproductive ability in the female life cycle, and which is the permanent cessation of menstruation. After menopause, the ovaries cut off the production of estrogen, after which important symptoms and diseases occur for women’s health due to estrogen deficiency. The aim of this study is to investigate the clinical, hormonal and biochemical parameters on bone mineral density (BMD) in postmenopausal women.<br /> <b>Method: </b>535 postmenopausal women were included in the study. Demographical parameters, biochemical, and hormonal serum levels were investigated. These values were statistically analyzed with Pearson correlation test with BMD values.<br /> <b>Results:</b> Significantly positive correlation is detected between patient’s height and lumbar T score (LtotT), lumbar Z score (LtotZ), and femoral T score (FtotT) (p=0.00, p=0.001, and p=0.00). Positive correlation was detected between patient’s weight and body mass index, and LtotT, LtotZ, FtotT, and femoral Z score (FtotZ) scores (p=0.00). Significantly negative correlation was detected between patient’s aspartate transaminase (AST) values and FtotT and FtotZ scores (p=0.002, p=0.004). Positive correlation was detected between patient’s phosphate (P) values, and FtotT and FtotZ scores (p=0.012, p=0.030). Negative correlation was detected between patient’s magnesium (Mg) values, and LtotT and LtotZ scores (p=0.016, p=0.032).<br /> <b>Conclusions:</b> BMD values are positively related with height, weight, serum phosphate levels, and negatively related with serum AST and Mg levels in postmenopausal women.