Structural Attributes of Organic Compounds for UV-Spectrophotometric Determination of Dissociation Constant – A Systematic Review-Reference-Cited by-同舟云学术

Structural Attributes of Organic Compounds for UV-Spectrophotometric Determination of Dissociation Constant – A Systematic Review

Published:2022-02-28 Issue:1 Volume:38 Page:85-93
ISSN:2231-5039
Container-title:Oriental Journal Of Chemistry
language:en
Short-container-title:Orient. J. Chem

Author:

Thangavel Neelaveni¹^ORCID,Al Bratty Mohammad¹^ORCID,Hassan Al Hazmi Hassan Al Hazmi¹,Asim Najmi Asim Najmi¹^ORCID,Sivadasan Durgaramani²^ORCID

Affiliation:

1. 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Saudi Arabia.

2. 2Department of Pharmaceutics, College of Pharmacy, Jazan University, Saudi Arabia.

Abstract

UV-spectrophotometric determination of dissociation constant (pKa) is used routinely in various research fields. This review highlights the structural attributes of organic compounds that exhibit distinct pH-sensitive UV-absorbance for ionized and unionized species qualifying for pKa measurement. Organic compounds must possess a double bond, the chromophore adjacent to the ionizing functional group. Compounds bearing up to five sigma bonds between the chromophore and ionizing group are eligible for UV-spectrophotometric determination of pKa. This review serves as a quick guide for knowledge about structural requirements expediting pKa determination by UV-spectrophotometry. Besides, the study also identified the gap in research on pKa in drug discovery and food chemistry, revealing the necessity of determining pKa at the early stages of drug and food research to enhance the success rate in their development.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

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