Synthesis and Biological Evaluation of Newly Synthesized Halogenated Flavones

Abstract

In the present investigation, newly chalcones derivatives of flavonoids (E)-3-(2-chlorophenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one and 2-(2-chlorophenyl)-4H-chromen-4-one synthesized through the Claisen-Schmidt condensation reaction. The initial structure of the newly synthesized compounds have been verified by FT-IR, 1HNMR, and 13C NMR spectroscopic methods. These two flavones were evaluated for their antibacterial activity using the Kuber agar well diffusion method on the bacterium Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The results displayed that both compounds have superior antibacterial activity against bacteria, S. aureus and E. coli.