Molecular Interactions and Aggregation Behavior of Cloxacillin Sodium in Water and Aqueous NaCl Solutions through Volumetric and Ultrasonic Sound Velocity Studies at 298.15 KMolecular Interactions and Aggregation Behavior of Cloxacillin Sodium in Water and Aqueous NaCl Solutions through Volumetric and Ultrasonic Sound Velocity Studies at 298.15 K

Abstract

Molecular interactions and aggregation behavior of cloxacillin sodium (CloNa) in water and aqueous NaCl solutions was studied through volumetric and ultrasonic sound velocity method at 298.15 K and atmospheric pressure. Density, ρ, and ultrasonic sound velocity, u, of cloxacillin sodium in water and aqueous NaCl solutions were measured with a digital density and ultrasonic sound velocity analyzer (DSA 5000, Anton Paar, Austria). And from the investigational data, apparent molar volume, ϕn, adiabatic compressibility, ϕS, apparent molar adiabatic compressibility, ϕk, limiting apparent molar volume, ϕn0, limiting apparent molar adiabatic compressibility, ϕk0, and aggregation concentration, CMC of cloxacillin sodium was calculated. The outcomes indication exhibits very significant evidence about the interactions among solute-solvent-co-solute (solute-solute, solute-solvent) and aggregation behavior in the aqueous environment and this result would be useful for the drug action in human body with pharmacological applications.