Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps-Reference-Cited by-同舟云学术

Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps

Published:2024-02-22 Issue: Volume: Page:33-48
ISSN:
Container-title:Exploration of Asthma & Allergy
language:
Short-container-title:Explor Asthma Allergy

Author:

Klimek Ludger¹^ORCID,Förster-Ruhrmann Ulrike²^ORCID,Olze Heidi²^ORCID,Beule Achim G.³^ORCID,Chaker Adam M.⁴^ORCID,Hagemann Jan⁵^ORCID,Huppertz Tilmann⁵,Hoffmann Thomas K.⁶,Dazert Stefan⁷^ORCID,Deitmer Thomas⁸,Strieth Sebastian⁹^ORCID,Wrede Holger¹⁰,Schlenter Wolfgang¹¹,Welkoborsky Hans-Jürgen¹²^ORCID,Wollenberg Barbara¹³^ORCID,Becker Sven¹⁴,Bärhold Frederike¹⁴,Klimek Felix¹,Casper Ingrid¹^ORCID,Zuberbier Jaron²^ORCID,Rudack Claudia¹⁵^ORCID,Cuevas Mandy¹⁶,Hintschich Constantin A.¹⁷^ORCID,Guntinas-Lichius Orlando¹⁸^ORCID,Stöver Timo¹⁹,Bergmann Christoph²⁰^ORCID,Werminghaus Pascal²¹,Pfaar Oliver²²^ORCID,Gosepath Jan²³,Gröger Moritz²⁴^ORCID,Beutner Caroline²⁵,Laudien Martin²⁶,Weber Rainer K.²⁷,Hildenbrand Tanja²⁸^ORCID,Hoffmann Anna-Sophie²⁹,Bachert Claus³⁰

Affiliation:

1. Center for Rhinology and Allergology, 65183 Wiesbaden, Germany

2. Department of Otorhinolaryngology, Charité – Universitätsmedizin Berlin, 10117 Berlin, Germany

3. Department of Otorhinolaryngology, Münster University Hospital, 48149 Münster, Germany; Department of Otorhinolaryngology, Head and Neck Surgery of Greifswald University Medical Center, 17475 Greifswald, Germany

4. Department of Otorhinolaryngology, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; Center for Allergy and Environment (ZAUM), TUM School of Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany

5. Department of Otorhinolaryngology, Mainz University Medical Center, 55131 Mainz, Germany

6. Department of Otorhinolaryngology, Ulm University Hospital, 89081 Ulm, Germany

7. Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth Hospital, 44787 Bochum, Germany

8. German Society for Otorhinolaryngology, Head and Neck Surgery, 53113 Bonn, Germany

9. Clinic and Polyclinic for Otorhinolaryngology, Bonn University Hospital, 53127 Bonn, Germany

10. Ear, Nose and Throat Specialist, 32052 Herford, Germany

11. Medical Association of German Allergists, 65183 Wiesbaden, Germany

12. Clinic for Otorhinolaryngology, Hanover Hospital, 30167 Hannover, Germany

13. Department of Otorhinolaryngology, TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany

14. Department of Otorhinolaryngology, University Hospital Tübingen, 72016 Tübingen, Germany

15. Department of Otorhinolaryngology, Münster University Hospital, 48149 Münster, Germany

16. Clinic and Polyclinic for Otorhinolaryngology, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany

17. Clinic and Polyclinic for Otorhinolaryngology, University Hospital Regensburg, 93053 Regensburg, Germany

18. Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany

19. Frankfurt University Ear, Nose and Throat Clinic, 60596 Frankfurt am Main, Germany

20. Practice for Otorhinolaryngology, Clinic RKM 740, 40549 Düsseldorf, Germany

21. Practice for Ear, Nose and Throat Medicine and Allergology, 40476 Düsseldorf, Germany

22. Department of Otorhinolaryngology, University Hospital Giessen and Marburg GmbH, Marburg site, Philipps University Marburg, 35037 Marburg, Germany

23. Department of Otorhinolaryngology, HSK Wiesbaden, 65199 Wiesbaden, Germany

24. Clinic and Polyclinic for Otorhinolaryngology, LMU University Hospital, 80336 Munich, Germany

25. Clinic for Dermatology, Venereology and Allergology, Allergy Center South Lower Saxony, University Medical Center Göttingen, 37075 Göttingen, Germany

26. Department of Otorhinolaryngology, Kiel University Hospital, 24105 Kiel, Germany

27. Department of Otorhinolaryngology, Karlsruhe Municipal Hospital, 76133 Karlsruhe, Germany

28. Department of Otorhinolaryngology, University Medical Center Freiburg, 79106 Freiburg, Germany

29. Department of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany

30. Department of Otorhinolaryngology, Ghent University Hospital, 9000 Ghent, Belgium

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and paranasal sinuses. Eosinophilic inflammation is described as a common endotype. The anti-interleukin-5 (IL-5) antibody mepolizumab was approved in November 2021 as an add-on therapy to intranasal glucocorticosteroids for the treatment of adults with severe CRSwNP when systemic glucocorticosteroids or surgery do not provide adequate disease control. While national and international recommendations exist for the use of mepolizumab in CRSwNP, therapy monitoring and follow-up documentation are required, and therapy discontinuation has not been adequately established yet. In this paper, recommendations for monitoring the course and efficacy of therapy as well as for reviewing the duration and possible termination of therapy are provided. For this purpose, a literature search was performed to analyze previous data on the treatment of CRSwNP with mepolizumab and to determine the available evidence by searching MEDLINE, PubMed, and the national and international trial and guideline registries and the Cochrane Library. Human studies published in the period up to and including October 2022 were considered. Based on the international literature and previous experience, recommendations for follow-up, adherence to therapy intervals and possible therapy breaks, as well as termination of therapy when using mepolizumab for the indication CRSwNP in the German health care system are given by an expert panel on the basis of a documentation sheet.

Publisher

Open Exploration Publishing

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