Natural killer cell-mediated immunopathology in recurrent pregnancy losses-Reference-Cited by-同舟云学术

Natural killer cell-mediated immunopathology in recurrent pregnancy losses

Published:2022-10-30 Issue:5 Volume:2 Page:693-722
ISSN:2768-6655
Container-title:Exploration of Immunology
language:en
Short-container-title:Explor Immunol

Author:

Luu Thanh¹^ORCID,AlSubki Lujain¹^ORCID,Wolf Katherine²^ORCID,Thees Amy²^ORCID,Ganieva Umida²^ORCID,Dambaeva Svetlana²^ORCID,Beaman Kenneth²^ORCID,Kwak-Kim Joanne³^ORCID

Affiliation:

1. Reproductive Medicine and Immunology, Obstetrics and Gynecology, Clinical Sciences Department, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL 60061, USA

2. Clinical Immunology Laboratory, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA

3. Reproductive Medicine and Immunology, Obstetrics and Gynecology, Clinical Sciences Department, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL 60061, USA; Clinical Immunology Laboratory, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA

Abstract

Natural killer (NK) cells have a dual role in human reproduction for maternal-fetal tolerance and protection from infection. During the ovarian cycle and pregnancy, peripheral NK (pNK) and uterine NK (uNK) cells dynamically change their proportions and cytotoxicities to prepare and accommodate invading trophoblast and maintain pregnancy. However, dysregulated pNK and uNK cell proportions and cytotoxic activities have been associated with aberrant spiral artery remodeling and trophoblast invasion, leading to implantation failures and recurrent pregnancy losses (RPLs). This review will focus on the role of NK cells in RPLs reviewing the ontogeny of NK cells, changes in pNK and uNK cell levels, and activities during the ovarian cycle, normal pregnancy, and RPL. In addition, the immunopathological role of NK cells in endometrial/decidual vascular development and killer immunoglobin-like receptor (KIR) and human leukocyte antigen (HLA)-C interactions are discussed.

Publisher

Open Exploration Publishing

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