Adiponectin as anti-inflammatory marker in developmen of allergic asthma

Abstract

Factors that could contribute to the pathogenesis of asthma in obese include low-grade inflammation, impaired metabolism and dysfunctional adipose tissue secretion. Because аdiponectin (ADPN) is involved in the mechanisms of asthma inflammation, the aim of the study is to evaluate the correlation between ADPN as inflammatory marker for obesity, with other inflammatory cytokines that have synergistic effect in intensity of airway inflammation in obesity. Methods implemented were immunoassay technique and immunoturbidimetric method. Statistical analysis was performed with SPSS. A total of 90 practically healthy subject and patients with asthma from 20 to 25 years old were evaluated and divided into two subjects using BMI classification. Based on the mean value of IL-6 and CRP in studied population (p<0.01), IL-6 can be considered as surrogate marker for obesity and CRP for obesity and asthma. The differences in ADPN (p<0.01) between groups show that ADPN produced and released by adipose tissue might be responsible for chronic inflammation related to obesity. Based on the obtained data for positive correlation of IL-6 (r = 0.470) and CRP (r = 0.660) with BMI, adipose tissue could be a dynamic factor for producing inflammatory markers. Negative correlation of ADPN and BMI (r = -0.481) shows that obesity may be a contributor to allergic asthma, because adiponectin as anti-inflammatory protein is decreased. Our study showed that ADPN as early anti-inflammatory marker has the potential to reduce allergy sensitization and CRP and IL-6 have synergistic effect in the intensity of airway inflammation in obesity. Key words: adiponectin, obesity, asthma, inflammatory markers, CRP, IL-6