Abstract
In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P
Subject
General Earth and Planetary Sciences,General Engineering,General Environmental Science
Reference30 articles.
1. Abdel-Emam RA, Ali MF. Effect of l-carnitine supplementation on lead acetate-induced liver cell apoptosis and inflammation: Role of caspase-3 and gly- cogen synthase kinase-3β enzymes. Life Sci 2022; 291: 120-277.
2. Adrogué HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 2007; 356(19): 1966-78.
3. Alaedin M. Effect of an inflammatory stimulus on mitochondrial fun1ctionality in liver cells of dairy cows, Doctoral dissertation, Universitäts-und Landesbibliothek, Bonn 2021; 22-4.
4. Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Miedema MD, Munoz D, Smith Jr SC, Virani SS, Williams SR KA, Ye- boah J, Ziaeian B. ACC/AHA guideline on the pri- mary prevention of cardiovascular disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2019; 140(11): e596-e646.
5. Beutler E, Duron O, Kelly BM. Improved method for determination of blood glutathione. J Lab Clin Med 1963; 61: 882-8.