Proof-of-Concept Analysis of a Deep Learning Model to Conduct Automated Segmentation of OCT Images for Macular Hole Volume

Abstract

BACKGROUND AND OBJECTIVE: To determine whether an automated artificial intelligence (AI) model could assess macular hole (MH) volume on swept-source optical coherence tomography (OCT) images. PATIENTS AND METHODS: This was a proof-of-concept consecutive case series. Patients with an idiopathic full-thickness MH undergoing pars plana vitrectomy surgery with 1 year of follow-up were considered for inclusion. MHs were manually graded by a vitreoretinal surgeon from preoperative OCT images to delineate MH volume. This information was used to train a fully three-dimensional convolutional neural network for automatic segmentation. The main outcome was the correlation of manual MH volume to automated volume segmentation. RESULTS: The correlation between manual and automated MH volume was R 2 = 0.94 ( n = 24). Automated MH volume demonstrated a higher correlation to change in visual acuity from preoperative to the postoperative 1-year time point compared with the minimum linear diameter (volume: R 2 = 0.53; minimum linear diameter: R 2 = 0.39). CONCLUSION: MH automated volume segmentation on OCT imaging demonstrated high correlation to manual MH volume measurements. [ Ophthalmic Surg Lasers Imaging Retina . 2022;53(4):208–214.]