STRUCTURAL POLYMORPHISM OF CYP2D6 AND CYP2C19 GENES MODIFIES THE EFFICACY AND TOXICITY OF PHARMACOTHERAPY FOR DEPRESSIVE STATES

Author:

Yakovleva O. A.1,Semenenko S. I.1,Zhamba A. O.1,Hoina-Kardasevich O. Yu.1

Affiliation:

1. National Pirogov Memorial Medical University, Vinnytsya (Vinnytsya, Ukraine)

Publisher

Poltava State Medical University

Reference30 articles.

1. Haustova OO. Tryvozhno-depresyvni rozlady v umovakh dystersu viiny v Ukraini. Consilium. 2022;4(63):22-24. Dostupno: https://heathua. com/article/71710-trivozhnodepresivn-rozladi-vumovah-distressu-vjni-vukran. [in Ukrainian].

2. Hodgson K, Tansey K, Dernovsek MZ, Hauser J, Henigsberg, N, Maier W, et al. Genetic differences in cytochrome P450 enzymes and antidepressant treatment response. J Psychopharmacol. 2014;28:133-41.

3. Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138(1):103-41.

4. Fabbri C, Serretti A. Pharmacogenetics of major depressive disorder: top genes and pathways forward clinical applications. Curr Psychiatry Rep. 2015;17:50-70.

5. Yakovleva OA, Semenenko SI, Zhamba AO, Hoina-Kardasevich OY, Vitruk TK. Kontrol farmakohenetyky fermentiv biotransformatsii likarskykh zasobiv – instrument dlia zabezpechennia personalizovanoi medytsyny. Bulletin of problems in biology and medicine. 2023;2(169):121-130. DOI: 10.29254/ 2077-4214-2023-2-169-121-130. [in Ukrainian].

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