Author:
Jatakanon A,Lim S,Kharitonov S A,Chung K F,Barnes P J
Abstract
BACKGROUND: Eosinophils in induced sputum and exhaled nitric oxide (NO) are currently used as non-invasive markers in the assessment of airway inflammation in asthma. As both sputum eosinophils (%) and exhaled NO are raised in asthmatic subjects not receiving inhaled steroids and decreased following corticosteroid therapy, a relationship between them is plausible. METHODS: Exhaled NO was measured by chemiluminescence analyser, sputum induction by 3.5% saline inhalation, and bronchial responsiveness was measured as PC20FEV1 methacholine in 35 stable asthmatic patients using beta 2 agonist alone and the correlation between these non-invasive markers of airway inflammation was studied. RESULTS: There were significant correlations between exhaled NO and PC20 (r = -0.64), exhaled NO and sputum eosinophils (%) (r = 0.48), and also between sputum eosinophils (%) and PC20 (r = -0.40). CONCLUSION: The correlation between exhaled NO and PC20 suggests that exhaled NO or the mechanisms leading to its increase may contribute to airway hyperresponsiveness in asthma. Furthermore, the relationship between sputum eosinophils (%), exhaled NO, and PC20 highlight the potential use of eosinophils (%) in induced sputum and exhaled NO to monitor the severity of asthma.
Subject
Pulmonary and Respiratory Medicine
Reference21 articles.
1. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide;Kharitonov, S.A.; O’Connor, B.J.; Evans, D.J.; Barnes, P.J.;Am J Respir Crit Care Med,1995
2. Expired nitric oxide levels during treatment of acute asthma;Massaro, A.F.; Gaston, B.; Kita, D.; Fanta, C.; Stamler, J.S.; Drazen, J.M.;Am J Respir Crit Care Med,1995
3. Exhaled nitric oxide is increased in asthma;true;Chest,1995
4. Effect of shortand long-acting inhaled 2 agonists on exhaled nitric oxide in asthmatic patients;Yates, D.H.; Kharitonov, S.A.; Barnes, P.J.;Eur Respir J,1997
5. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients;Kharitonov, S.A.; Yates, D.H.; Barnes, P.J.;Am J Respir Crit Care Med,1996
Cited by
596 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献