Retinal pigment epithelial change and partial lipodystrophy.

Author:

Davis T. M.,Holdright D. R.,Schulenberg W. E.,Turner R. C.,Joplin G. F.

Publisher

BMJ

Subject

General Medicine

Reference19 articles.

1. Singular case of absence of adipose matter in the upper half of the body;Mitchell, S.W.;Am J Med Sci; The patient described in this report illustrates a further association which should be considered in the management of such patients. The extensive deposition of material in the basement membrane of the retina is ppobably not coincidental and might be analogous to glomerular basement membrane changes seen in the mesangiocapillary glomerulonephritis which can be associated with partial lipodystrophy. Alternatively, the combination of retinal abnormalities, partial lipodystrophy with impaired insulin sensitivity, and hypocomplementaemia might be due to deletion of a short segment of chromosome

2. The young woman described in this report illustrates many of the features of a 'typical' patient with progressive partial lipodystrophy. In addition, she has evidence of retinal pigment epithelial and basement membrane changes, a hitherto unpublished association.* Although little is known of the aetiology and pathogenesis of the lipoatrophic disorders, a careful characterization of their clinical, biochemical and metabolic manifestations may provide valuable clues for future study

3. The syndromes of total lipodystrophy and of partial lipodystrophy;Senior, B.; Gellis, S.S.;Pediatrics

4. Lipodystrophy of the extremities. A dominantly inherited syndrome associated with lipoatrophic diabetes;Kobberling, J.Willms; B., Katterman; R.; Creutzfeldt, W.;Humangenetik,1975

5. Blood lipid levels, thyroid status, and glucose tolerance in progressive partial lipodystrophy;Rifkind, R.M.; Boyle, A.J.; Gale, M.;J Clin Pathol,1967

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