Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach

Author:

Yamashita Masatoshi,Kagitani-Shimono Kuriko,Hirano YoshiyukiORCID,Hamatani Sayo,Nishitani Shota,Yao Akiko,Kurata Sawa,Kosaka Hirotaka,Jung Minyoung,Yoshida Tokiko,Sasaki Tsuyoshi,Matsumoto Koji,Kato Yoko,Nakanishi Mariko,Tachibana Masaya,Mohri Ikuko,Tsuchiya Kenji J,Tsujikawa Tetsuya,Okazawa Hidehiko,Shimizu Eiji,Taniike Masako,Tomoda Akemi,Mizuno YoshifumiORCID

Abstract

IntroductionNeuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures.Methods and analysisWe will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD.Ethics and disseminationThe study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.

Funder

Research Grants from the University of Fukui

Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics

Japan Society for the Promotion of Science

Publisher

BMJ

Subject

General Medicine

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