The patient perspective on absence of disease activity in rheumatoid arthritis: a survey to identify key domains of patient-perceived remission

Author:

van Tuyl Lilian H DORCID,Sadlonova Martina,Hewlett Sarah,Davis Bev,Flurey Caroline,Goel Niti,Gossec LaureORCID,Heegaard Brahe Cecilie,Hill Catherine L,Hoogland Wijnanda,Kirwan John,Hetland Merete L,van Schaardenburg Dirkjan,Smolen Josef SORCID,Stamm Tanja,Voshaar Marieke,Wells George A,Boers Maarten

Abstract

BackgroundGuidelines suggest treatment in rheumatoid arthritis (RA) to target remission, in close consultation with the patient. Our recent qualitative study of the patients' perspective on remission in RA identified 26 domains. The current study aimed to identify a short list of the most important aspects to inform future research.MethodsPatients with RA from the Netherlands, the UK, Austria, Denmark, France and the USA completed a survey that contained all domains identified in our qualitative study. They rated domains for importance (‘not important’, ‘important’ or ‘essential’ to characterise a period of remission) and if important or essential, whether this domain needs to be ‘less’, ‘almost gone’ or ‘gone’ to reflect remission. Respondents were also asked to determine their personal top 3 most important/essential domains. Frequency of specific domains in the top 3 was calculated, and domains were sorted on the percentage of patients that evaluated a particular domain as ‘essential’.ResultsOf 274 respondents, 75% were female, mean (SD) age 57(13) years, disease duration 12(9) years. The top 3 were as follows: pain (67%), fatigue (33%) and independence (19%); domains most frequently rated as ‘essential’ were as follows: pain (60%), being mobile (52%), physical function (51%), being independent (47%) and fatigue (41%). Pain needed to be less (13%), almost gone (42%) or gone (45%) to reflect remission. Similar patterns were seen for fatigue, independence, mobility and physical functioning.ConclusionPatients identified pain, fatigue and independence as the most important domains of RA disease activity that need to be improved to reflect remission.

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference32 articles.

1. World Health Organization and International League of Associations for Rheumatology core endpoints for symptom modifying antirheumatic drugs in rheumatoid arthritis clinical trials;Boers;J Rheumatol Suppl,1994

2. Development of a disease activity score based on judgment in clinical practice by rheumatologists;Van der Heijde;J Rheumatol,1993

3. Relative efficiencies of physician/assessor global estimates and patient questionnaire measures are similar to or greater than joint counts to distinguish adalimumab from control treatments in rheumatoid arthritis clinical trials;Pincus;J Rheumatol,2008

4. Similar prediction of mortality by the health assessment questionnaire in patients with rheumatoid arthritis and the general population;Sokka;Ann Rheum Dis,2004

5. Physical function continues to improve when clinical remission is sustained in rheumatoid arthritis patients;Radner;Arthritis Res Ther,2015

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