A phase 2, randomised, placebo-controlled clinical trial of blisibimod, an inhibitor of B cell activating factor, in patients with moderate-to-severe systemic lupus erythematosus, the PEARL-SC study

Author:

Furie R A,Leon G,Thomas M,Petri M A,Chu A D,Hislop C,Martin R S,Scheinberg M A

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference27 articles.

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3. The role of BAFF in immune function and implications for autoimmunity;Kalled;Immunol Rev,2005

4. A novel modality of BAFF-specific inhibitor AMG623 peptibody reduces B-cell number and improves outcomes in murine models of autoimmune disease;Hsu;Clin Exp Rheumatol,2012

5. Phase 1a Single- and Phase 1b Multiple-Dose Studies of AMG 623 (an anti-BAFF peptibody) in Systemic Lupus Erythematosus (SLE);Stohl;Arthritis Rheum,2008

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