Author:
Amin Ramzi,Wu Carly Yanlin,Lee Jill Cheng Sim,Ananta Mihir Gudi
Abstract
Primary signet-ring cell carcinoma of the uterus is rare and requires exclusion of possible metastatic tumour to the uterus. We report a case of a woman in her 70s who underwent hysteroscopy and a polypectomy for a polyp arising from the uterine wall. On histological examination, malignant cells with signet-ring cell morphology were found within the fragments of endometrial tissue. Immunohistochemical studies indicated a metastatic adenocarcinoma possibly from the gastrointestinal tract. Additional radiological investigations revealed a possible primary gastric tumour, which was further confirmed on subsequent biopsies. This case illustrates that gastric carcinomas can rarely metastasise to the endometrium and highlights the importance of clinical correlation in arriving at the final diagnosis.
Reference12 articles.
1. Kim YH , Lee SJ , Lee SU , et al . Primary signet ring cell carcinoma of the uterine cervix: a case report. Medicine (Baltimore) 2021;100:e26844. doi:10.1097/MD.0000000000026844
2. Giordano G , Pizzi S , Berretta R , et al . A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: immunohistochemical and molecular studies and review of the literature. World J Surg Oncol 2012;10:7. doi:10.1186/1477-7819-10-7
3. WHO Classification of Tumours Editorial Board . Female genital tumours, WHO classification of tumours series, 5th Ed.; Vol. 4. Lyon (France) International Agency for Research on Cancer; 2020. Available: https://publications.iarc.fr/592
4. Akkalp AK , Ozyurek ES , Tetikkurt US , et al . Primary endometrial adenocarcinoma with signet-ring cells: a rarely observed case and review of the literature. Case Rep Obstet Gynecol 2015;2015:404692. doi:10.1155/2015/404692
5. Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT)