Intestinal damage in rotavirus and adenovirus gastroenteritis assessed by d-xylose malabsorption.

Author:

Mavromichalis J,Evans N,McNeish A S,Bryden A S,Davies H A,Flewett T H

Publisher

BMJ

Subject

Pediatrics, Perinatology, and Child Health

Reference12 articles.

1. The association between the presence of rotavirus and adenovirus in the lumen of the small intestine and a low blood-xylose suggests strongly that both these viruses can cause small intestinal dysfunction. Utilization of xylose by micro-organisms in the small intestine is not a real possibility; bacterial counts were low and these viruses do not metabolize xylose

2. It is tempting to speculate that xylose malabsorption is the result of mucosal damage by the virus (Bishop et al., 1973), but we have no proof of this because jejunal biopsy was not performed. The data indicate the importance of seeking pathogens in the intestinal fluid as well as in stools. We do not know the explanation of the symptoms in those infants where virus was found in the faeces only, but it is possible that the demonstrated viruses were not true pathogens

3. Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis;Bishop, R.F.; Davidson, G.P.; Holmes, I.H.; Ruck, B.J.;Lancet,1973

4. Importance of a new virus in acute sporadic enteritis in children;Davidson, G.P.; Bishop, R.F.; Townley, R.R.W.; Holmes, I.H.; Ruck, B.J.;Lancet,1975

5. Relation between viruses from acute gastroenteritis of children and newborn calves;Flewett, T.H.; Bryden, A.S.; Davies, H.A.; Woode, G.N.; Bridger, J.C.; Derrick, J.M.;Lancet,1974

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