Use of modern methods for diagnostics of diseases of the heptobiliary system

Abstract

In modern clinical veterinary practice, in the overwhelming majority of cases, the diagnosis associated with pathologies of the hepatobiliary system is established on the basis of a combination of clinical, laboratory and instrumental data, which is a rather laborious and cost-intensive process, which makes it relevant to search for new methods with more relevant. Laboratory assessment of the hepatobiliary system has several goals, including: determining the presence of hepatobiliary pathology, determining the presence of liver disease, including primary or secondary hepatitis, determining the definitive type of liver disease, and monitoring response to therapy or disease progression. We have comprehensively analyzed existing studies in the field of using various methods for diagnosing pathologies of the hepatobiliary system, identifying the most promising approaches from the point of view of veterinary hepatology for their further possible introduction into industry practice. The search and processing of scientific publications was carried out according to the recommendations of H. Snyder [10] for writing review articles. An assessment is given to the positive and negative sides of each technique.Based on the analyzed literature, it can be concluded that, despite the knowledge of the issues of hepatology and the diagnosis of liver diseases, there are gaps and weaknesses in any diagnostic model. Thus, one potential diagnostic model that is promising but little studied is the use of clearance tests. Functional tests allow not only to diagnose and differentiate hepatopathologies, but also to visualize their course and liver recovery.Also, unlike statistical tests, clearance tests allow you to evaluate the work of the liver in dynamics.