Evaluation of the prospects for the use of Danio Rerio (Zebrafish) as biological model in the context of the study of hepatotoxic effects

Abstract

This article describes the morphological structure of the zebrafish liver and its comparison with the organization of the liver of mammals, known methods for inducing liver pathologies in these fish, and assesses the prospects for using Danio rerio (Zebrafish) as biological models in the context of studying hepatotoxic effects.The scientific novelty of the publication lies in the complexity of the ongoing review of existing studies in the field of using model animals to assess various hepatotoxic effects, identifying the most promising approaches from the point of view of veterinary hepatology for their further possible introduction into industry practice.The information retrieval methodology was based on such general scientific methods of cognition as: a review of specialized search engines and databases of scientific and research data (Scopus, WoS, PubMed) over the past 10 years, of which the most informative ones were selected, analysis of the identified results, their comparison by relevance.Summing up the results of the search, we can conclude that the results of relevant experiments indicate the promise of studying hepatotoxic effects on zebrafish, which represent a promising and cost-effective alternative to other model objects. Danio rerio can reproduce in detail and with high accuracy the patterns of occurrence, development and outcome of pathological processes in mammalian organs due to the high level of genetic preservation and similar morphology and functions of organs. It is believed that further technical development and characterization of these biomodels in the context of the study of hepatotoxicity will provide new insights into the molecular and cellular mechanisms underlying disease pathogenesis, thereby providing multiple opportunities for the identification and validation of new therapeutic targets and treatments.