In Vivo Antimalarial Test of Artocarpin and in vitro Antimalarial Test of Artonin M Isolated from Artocarpus

Author:

Suhartati Tati,Epriyanti Eka,Borisha Inggit,Yandri ,Suwandi Jhons F.,Yuwono Suripto D.,Qudus Hardoko I.,Hadi Sutopo

Abstract

The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC50 of 0.3 μg/mL (5.967 x 10-7 M).

Publisher

Revista de Chimie SRL

Subject

General Chemistry,Materials Science (miscellaneous),Materials Chemistry,Process Chemistry and Technology,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Pharmacology, Toxicology and Pharmaceutics

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