Mechanism of Cross-Linking, Self-Assembly, Controlled Release, and Applications of Nanogels in Drug Delivery System

Abstract

Drug delivery system has been very important for achieving the last goal of precision medicine, also, among various drug carrier materials, nanogel is considered a promising one. Nanogels are a kind of material that have been proven very effective and specialized on targeted controlled release of drugs in medical therapies. Many researches and applications have used nanogels as an efficient drug carrier through its properties of loading and high capacity, and very high future expectations has been given to this material as a future idealized material in nano medical areas. This paper mainly discusses the key features of the nanogels including degradability and high drug capacity, as well as the mechanism of cross- linking mechanism and self assembly of nanogels in both physical and chemical ways. In addition, this paper explains how nanogels can carry different drugs and control-release the drug under different stimuli to aim the goal at targeted drugs delivery. Finally current research situations and future expectations of this topic are also proposed.