Author:
Shang Juanjuan,Hu Shunfeng,Wang Xin
Abstract
AbstractNatural killer (NK) cell belongs to innate lymphoid cell family that contributes to host immunosurveillance and defense without pre-immunization. Emerging studies have sought to understand the underlying mechanism behind NK cell dysfunction in tumor environments, and provide numerous novel therapeutic targets for tumor treatment. Strategies to enhance functional activities of NK cell have exhibited promising efficacy and favorable tolerance in clinical treatment of tumor patients, such as immune checkpoint blockade (ICB), chimeric antigen receptor NK (CAR-NK) cell, and bi/trispecific killer cell engager (BiKE/TriKE). Immunotherapy targeting NK cell provides remarkable advantages compared to T cell therapy, including a decreased rate of graft versus-host disease (GvHD) and neurotoxicity. Nevertheless, advanced details on how to support the maintenance and function of NK cell to obtain better response rate and longer duration still remain to be elucidated. This review systematically summarizes the profound role of NK cells in tumor development, highlights up-to-date advances and current challenges of therapy targeting NK cell in the clinical treatment of hematologic malignancies.
Funder
Shandong Provincial Natural Science Foundation
China Postdoctoral Science Foundation
National Natural Science Foundation
Key Research and Development Program of Shandong Province
Translational Research Grant of NCRCH
Taishan Scholars Program of Shandong Province
Shandong Provincial Engineering Research Center of Lymphoma
Academic Promotion Programme of Shandong First Medical University
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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