A review of 177Lu dosimetry workflows: how to reduce the imaging workloads?
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Published:2024-07-18
Issue:1
Volume:11
Page:
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ISSN:2197-7364
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Container-title:EJNMMI Physics
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language:en
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Short-container-title:EJNMMI Phys
Author:
Vergnaud LaureORCID, Dewaraja Yuni K., Giraudet Anne-Laure, Badel Jean-Noël, Sarrut David
Abstract
Abstract$$^{177}{\hbox {Lu}}$$
177
Lu
radiopharmaceutical therapy is a standardized systemic treatment, with a typical dose of 7.4 GBq per injection, but its response varies from patient to patient. Dosimetry provides the opportunity to personalize treatment, but it requires multiple post-injection images to monitor the radiopharmaceutical’s biodistribution over time. This imposes an additional imaging burden on centers with limited resources. This review explores methods to lessen this burden by optimizing acquisition types and minimizing the number and duration of imaging sessions. After summarizing the different steps of dosimetry and providing examples of dosimetric workflows for $$^{177}{\hbox {Lu}}$$
177
Lu
-DOTATATE and $$^{177}{\hbox {Lu}}$$
177
Lu
-PSMA, we examine dosimetric workflows based on a reduced number of acquisitions, or even just one. We provide a non-exhaustive description of simplified methods and their assumptions, as well as their limitations. Next, we detail the specificities of each normal tissue and tumors, before reviewing dose-response relationships in the literature. In conclusion, we will discuss the current limitations of dosimetric workflows and propose avenues for improvement.
Publisher
Springer Science and Business Media LLC
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