Author:
Stresman Gillian,Lal Sham,Bruce Jane,Nji Akindeh,Serge-Brice Assi,Mosoff Jonna,McGirr Alba,Gore-Langton Georgia,McGuire Michaela,Sinsai James,Lele Albertine,Tah-Monunde Mercy,Kouadio Zah-Bi,Anatole Mian,Konate-Toure Abibatou,Clarke Sian Elisabeth,Gosling Roland,Mbacham Wilfred Fon,Yavo William,Chico R. Matthew
Abstract
Abstract
Background
Perennial malaria chemoprevention (PMC) is a chemoprevention strategy endorsed by the World Health Organization (WHO) and is increasingly being adopted by National Malaria Programmes. PMC aims to reduce morbidity and mortality caused by malaria and anaemia in in young children through provision of antimalarial drugs at routine contact points with the local health system. This study aims to evaluate the impact of the programmatically-implemented country-tailored PMC programmes targeting children up to two years of age using sulfadoxine-pyrimethamine (SP) on the incidence of malaria and anaemia in children in Cameroon and Côte d’Ivoire.
Methods
We will assess the impact of PMC using passive and active monitoring of a prospective observational cohort of children up to 36 months of age at recruitment in selected study sites in Cameroon and Côte d’Ivoire. The primary and secondary outcomes include malaria, anaemia and malnutrition incidence. We will also conduct a time-series analysis of passively detected malaria and anaemia cases comparing the periods before and after PMC introduction. This study is powered to detect a 30% and 40% reduction of malaria incidence compared to the standard of care in Cameroon and Côte d’Ivoire, respectively.
Discussion
This multi-country study aims to provide evidence of the effectiveness of PMC targeting children in the first two years of life on malaria and anaemia and will provide important information to inform optimal operationalization and evaluation of this strategy.
Trial Registration
Cameroon - NCT05889052; Côte d’Ivoire - NCT05856357.
Publisher
Springer Science and Business Media LLC
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