Author:
Meng Qi,Chen Chen,Zhu Mingfang,Huang Yue
Abstract
Abstract
Background
Prior observational research has investigated the association between dietary patterns and Alzheimer’s disease (AD) risk. Nevertheless, due to constraints in past observational studies, establishing a causal link between dietary habits and AD remains challenging.
Methods
Methodology involved the utilization of extensive cohorts sourced from publicly accessible genome-wide association study (GWAS) datasets of European descent for conducting Mendelian randomization (MR) analyses. The principal analytical technique utilized was the inverse-variance weighted (IVW) method.
Results
The MR analysis conducted in this study found no statistically significant causal association between 20 dietary habits and the risk of AD (All p > 0.05). These results were consistent across various MR methods employed, including MR-Egger, weighted median, simple mode, and weighted mode approaches. Moreover, there was no evidence of horizontal pleiotropy detected (All p > 0.05).
Conclusion
In this MR analysis, our finding did not provide evidence to support the causal genetic relationships between dietary habits and AD risk.
Publisher
Springer Science and Business Media LLC
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