Evaluating the efficacy, impact, and feasibility of community-based house screening as a complementary malaria control intervention in southern Africa: a study protocol for a household randomized trial

Author:

Sangoro Onyango P.ORCID,Fillinger Ulrike,Saili Kochelani,Nkya Theresia Estomih,Marubu Rose,Masaninga Freddie,Trigo Sonia Casimiro,Tarumbwa Casper,Hamainza Busiku,Baltazar Candrinho,Mberikunashe Joseph,Chisanga Brian,Menale Kassie,Chanda Emmanuel,Mutero Clifford Maina

Abstract

Abstract Background Concerted effort to control malaria has had a substantial impact on the transmission of the disease in the past two decades. In areas where reduced malaria transmission is being sustained through insecticide-based vector control interventions, primarily long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), non-insecticidal complementary tools will likely be needed to push towards malaria elimination. Once interruption in local disease transmission is achieved, insecticide-based measures can be scaled down gradually and eventually phased out, saving on costs of sustaining control programs and mitigating any unintended negative health and environmental impacts posed by insecticides. These non-insecticidal methods could eventually replace insecticidal methods of vector control. House screening, a non-insecticidal method, has a long history in malaria control, but is still not widely adopted in sub-Saharan Africa. This study aims to add to the evidence base for this intervention in low transmission settings by assessing the efficacy, impact, and feasibility of house screening in areas where LLINs are conventionally used for malaria control. Methods A two-armed, household randomized clinical trial will be conducted in Mozambique, Zambia, and Zimbabwe to evaluate whether combined the use of house screens and LLINs affords better protection against clinical malaria in children between 6 months and 13 years compared to the sole use of LLINs. Eight hundred households will be enrolled in each study area, where 400 households will be randomly assigned the intervention, house screening, and LLINs while the control households will be provided with LLINs only. Clinical malaria incidence will be estimated by actively following up one child from each household for 6 months over the malaria transmission season. Cross-sectional parasite prevalence will be estimated by testing all participating children for malaria parasites at the beginning and end of each transmission season using rapid diagnostic tests. CDC light traps and pyrethrum spray catches (PSC) will be used to sample adult mosquitoes and evaluate the impact of house screening on indoor mosquito density, species distribution, and sporozoite rates. Discussion This study will contribute epidemiological data on the impact of house screening on malaria transmission and assess the feasibility of its implementation on a programmatic scale. Trial registration ClinicalTrials.gov PACTR202008524310568. Registered on August 11, 2020.

Funder

World Health Organization

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Reference57 articles.

1. WHO. World Malaria Report 2016 [Internet]. World Health Organization; 2016 [cited 2017 Oct 13]. Available from: http://apps.who.int/iris/bitstream/10665/252038/1/9789241511711-eng.pdf?ua=1

2. Alonso P, Noor AM. The global fight against malaria is at crossroads. Lancet. Elsevier. 2017;390:2532–4, 10112. https://doi.org/10.1016/S0140-6736(17)33080-5.

3. WHO. World malaria report 2019 [Internet]. 2019 [cited 2019 Dec 11]. p. 1–232. Available from: https://www.who.int/publications-detail/world-malaria-report-2019

4. World Health Organization. Global technical strategy for malaria 2016–2030. Global Malaria Programme [Internet]. 2015 [cited 2021 Mar 12]. Available from: http://apps.who.int/iris/bitstream/handle/10665/176712/9789241564991_eng.pdf;jsessionid=66E6DA665C88369AF0BA3A99E8525283?sequence=1

5. UNCTAD. Catalysing investment for transformative growth in africa.

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