Efficient 9α-hydroxy-4-androstene-3,17-dione production by engineered Bacillus subtilis co-expressing Mycobacterium neoaurum 3-ketosteroid 9α-hydroxylase and B. subtilis glucose 1-dehydrogenase with NADH regeneration-Reference-Cited by-同舟云学术

Efficient 9α-hydroxy-4-androstene-3,17-dione production by engineered Bacillus subtilis co-expressing Mycobacterium neoaurum 3-ketosteroid 9α-hydroxylase and B. subtilis glucose 1-dehydrogenase with NADH regeneration

Published:2016-07-29 Issue:1 Volume:5 Page:
ISSN:2193-1801
Container-title:SpringerPlus
language:en
Short-container-title:SpringerPlus

Author:

Zhang Xian,Rao Zhiming,Zhang Lele,Xu Meijuan,Yang Taowei

Funder

High-tech Research and Development Programs of China

National Natural Science Foundation of China

Jiangsu Province Science Fund for Distinguished Young Scholars

Natural Science Foundation of Jiangsu Province

China Postdoctoral Science Foundation Funded Project

Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

Jiangsu province "Collaborative Innovation Center for Advanced Industrial Fermentation" industry development program

111 Project

the Program of the Key Laboratory of Industrial Biotechnology,Ministry of Education,China

the Fundamental Research Funds for the Central Universities

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://link.springer.com/content/pdf/10.1186/s40064-016-2871-4.pdf

Reference34 articles.

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3. Angelova B, Mutafov S, Avramova T, Dimova I, Boyadjieva L (1996) 9Alpha-hydroxylation of 4-androstene-3,17-dione by resting Rhodococcus sp. cells. Process Biochem 31(2):179–184

4. Arnell R, Johannisson R, Lindholm J, Fornstedt T, Ersson B, Ballagi A, Caldwell K (2007) Biotechnological approach to the synthesis of 9 alpha-hydroxylated steroids. Prep Biochem Biotechnol 37(4):309–321

5. Bao T, Zhang X, Zhao X, Rao Z, Yang T, Yang S (2015) Regulation of the NADH pool and NADH/NADPH ratio redistributes acetoin and 2,3-butanediol proportion in Bacillus subtilis. Biotechnol J. doi: 10.1002/biot.201400577

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