Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

Author:

Lopes Alves Isadora,Vállez García David,Parente Andrea,Doorduin Janine,Dierckx Rudi,Marques da Silva Ana Maria,Koole Michel,Willemsen Antoon,Boellaard Ronald

Funder

Siemens

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging

Reference35 articles.

1. Odano I, Halldin C, Karlsson P, Varrone A, Airaksinen AJ, Krasikova RN, et al. [18 F]Flumazenil binding to central benzodiazepine receptor studies by PET. Neuroimage [Internet]. Elsevier Inc.; 2009. 45(3):891–902. Available from: http://dx.doi.org/ 10.1016/j.neuroimage.2008.12.005

2. Heiss WD, Grond M, Thiel A, Ghaemi M, Sobesky J, Rudolf J, et al. Permanent cortical damage detected by flumazenil positron emission tomography in acute stroke. Stroke. 1998;29(2):454–61.

3. Heiss WD, Kracht L, Grond M, Rudolf J, Bauer B, Wienhard K, et al. Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke [Internet]. 2000;31(2):366–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10657407 .

4. Atack JR, Scott-stevens P, Beech JS, Fryer TD, Hughes JL, Cleij MC, et al. Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one] occupancy of rat brain gamma—aminobutyric acid a receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidaxzo[1. J Pharmacol Exp Ther. 2007;320(3):1030–7.

5. Geeraerts T, Coles JP, Aigbirhio FI, Pickard JD, Menon DK, Fryer TD, et al. Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury. Ann Nucl Med [Internet]. 2011;25(6):396–405. [cited 2014 Nov 5] Available from: http://www.ncbi.nlm.nih.gov/pubmed/21461598 .

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