Author:
Sáez-Llorens Xavier,Velázquez F Raúl,Lopez Pio,Espinoza Felix,Linhares Alexandre C,Abate Hector,Nuñez Ernesto,Venegas Guillermo,Vergara Rodrigo,Jimenez Ana L,Rivera Maribel,Aranza Carlos,Richardson Vesta,Macias-Parra Mercedes,Palacios Guillermo Ruiz,Rivera Luis,Ortega-Barria Eduardo,Cervantes Yolanda,Rüttimann Ricardo,Rubio Pilar,Acosta Camilo J,Newbern Claire,Verstraeten Thomas,Breuer Thomas
Abstract
Abstract
Background
Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction.
Methods
Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines.
Results
From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged.
Conclusions
This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies.
Trial registration
Clinical study identifier 999910/204 (SERO-EPI-IS-204)
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,General Medicine
Reference41 articles.
1. Wyllie R: Ileus, adhesions, intussusception and closed-loop obstructions. Nelson textbook of pediatrics. Edited by: Behrman RE, Kliegman RM, Arvin AM. 1997, Philadelphia: WB Saunders, 1072-1074. 15
2. Bhisitkul DM, Todd KM, Listernick R: Adenovirus infection and childhood intussusceptions. Am J Dis Child. 1992, 146: 1331-1333.
3. Mulcahy DL, Kamath KR, De Silva LM, Hodges S, Carter IW, Cloonan MJ: A two-part study of the aetiological role of rotavirus in intussusceptions. J Med Virol. 1982, 9: 51-55. 10.1002/jmv.1890090108.
4. Asano Y, Yoshikawa T, Suga S, Hata T, Yamazaki T, Yazaki T: Simultaneous occurrence of human herpesvirus 6 infection and intussusception in three infants. Pediatr Infect Dis J. 1991, 10: 335-337. 10.1097/00006454-199104000-00015.
5. Nakagomi T: Rotavirus infection and intussusception: a view from retrospect. Microbiol Immunol. 2000, 44: 619-628.
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