Abstract
Abstract
Background
Filamentous basidiomycetes are mainly considered to be respiratory tract colonizers but the clinical significance of their isolation in a specimen is debatable. Hormographiella aspergillata was first reported as a human pathogen in 1971. We discuss the role of this mold as a pathogen or colonizer and give an update on diagnostic tools and in vitro antifungal susceptibility.
Case presentation
We identified three cases of H. aspergillata with respiratory symptoms in a short period of time. One invasive infection and two colonizations were diagnosed. Culture supernatants showed that H. aspergillata can produce galactomannan and β-D-glucan but not glucuronoxylomannan. For the first time, isavuconazole susceptibility was determined and high minimum inhibitory concentrations (MICs) were found. Liposomal amphotericin B and voriconazole have the lowest MICs.
Conclusion
To date, 22 invasive infections involving H. aspergillata have been reported. On isolation of H. aspergillata, its pathogenic potential in clinical settings can be tricky. Molecular identification and antifungal susceptibility testing are essential considering high resistance against several antifungal therapies.
Publisher
Springer Science and Business Media LLC
Reference29 articles.
1. Brandt ME. Filamentous Basidiomycetes in the clinical laboratory. Curr Fungal Infect Rep. 2013;7(3):219–23.
2. Speller DE, MacIver AG. Endocarditis caused by a Coprinus species: a fungus of the toadstool group. J Med Microbiol. 1971;4(3):370–4.
3. Gené J, Guillamon JM, Guarro J, Pujol I, Ulfig K. Molecular characterization, relatedness and antifungal susceptibility of the basidiomycetous Hormographiella species and Coprinus cinereus from clinical and environmental sources. Antonie Van Leeuwenhoek. 1996;70(1):49–57.
4. de Oliveira TB, Lopes VCP, Barbosa FN, Ferro M, Meirelles LA, Sette LD, et al. Fungal communities in pressmud composting harbour beneficial and detrimental fungi for human welfare. Microbiology. 2016;162(7):1147–56.
5. Nenoff P, Friedrich T, Schwenke H, Mierzwa M, Horn LC, Haustein UF. Rare fatal simultaneous mould infection of the lung caused by Aspergillus flavus and the basidiomycete Coprinus sp. in a leukemic patient. J Med Vet Mycol Bi-Mon Publ Int Soc Hum Anim Mycol. 1997;35(1):65–9.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献