Author:
Ebrahem Eman M. M.,Sayed Galal H.,Gad Gehan N. A.,Anwer Kurls E.,Selim Adli A.
Abstract
AbstractBackgroundHepatocellular carcinoma (HCC) is one of the most dangerous cancers in all the world. This study focused on prevention and therapy of hepatocellular carcinoma (HCC) usingMoringa oleiferaextract combined with vitamin C and selenium in a nanoplatform (MO/asc.-Se-NPs).ResultsFull characterization of MO/asc.-Se-NPs was performed by using different analytical techniques (TEM, DLS, zeta-sizer), and its antioxidant capacity was measured by DPPH assay. Biodistribution study was performed with the aid of radiolabeling technique using technetium-99m in normal albino mice. HCC was induced in Wister albino rats to evaluate the efficiency of MO/asc.-Se-NPs in the treatment of HCC. The biomarker analysis (ALT, AST and ALB) shows improvement in its values in prevention and treated groups by using MO/asc.-Se NP. The levels of inflammatory marker interleukin 6 (IL6 tissue homogenate) was improved by decreasing its values in these two groups also. Histology section of tissue liver showed alleviation in treated and prevention groups.ConclusionsIn conclusion, MO/asc.-Se-NPs can be used as a potential agent for prevention and treatment of HCC after further preclinical studies.
Funder
Egyptian Atomic Energy Authority
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry,Pharmaceutical Science,Oncology,Biomedical Engineering
Reference81 articles.
1. Abdulwahab HG, Harras MF, El Menofy NG, Hegab AM, Essa BM, Selim AA et al (2020) Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study. Bioorg Med Chem 28(23):115759
2. Akbari B, Baghaei-Yazdi N, Bahmaie M, MahdaviAbhari F (2022) The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors 23:14
3. Akhter T (2023) To study the composition of minerals and vitamins of some fresh vegetables with special reference to the Kullu District of Himachal Pradesh India. Sustaina Agri Food Environ Res 12:1
4. Aljuhr SA, Abdelaziz G, Essa BM, Zaghary WA, Sakr TM (2021) Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/C@ SeNPs in rats: Synthesis, characterization, biochemical, radio-biodistribution, molecular and histopathological studies. Bioorg Chem 117:105412
5. Al-Sayed E, Abdel-Daim MM, Khattab MA (2019) Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride-induced hepatotoxicity in mice Impact on oxidative stress, inflammation, and apoptosis. Phytother Res 33(2):461–470
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献