Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos-Reference-Cited by-同舟云学术

Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos

Published:2024-08-19 Issue:1 Volume:22 Page:
ISSN:1477-3155
Container-title:Journal of Nanobiotechnology
language:en
Short-container-title:J Nanobiotechnol

Author:

Zhou Renyi,Guo Jiarong,Jin Zhe

Abstract

AbstractThis study investigated the mechanism of the extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was synthesized and evaluated for its impact on chondrocyte viability and neutrophil extracellular traps (NETs) formation. In an OA rat model, GMOCS-Exos promoted cartilage regeneration and inhibited NETs formation. Transcriptome sequencing identified TGFB1 as a key gene, with GMOCS-Exos activating Nrf2 signaling through TGFB1. Depletion of TGFB1 hindered the cartilage-protective effect of GMOCS-Exos. This study sheds light on a promising therapeutic strategy for osteoarthritis through GMOCS-Exos-mediated TGFB1/Nrf2 pathway modulation.

Funder

Liaoning Provincial Science and Technology Program

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s12951-024-02713-z.pdf

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